Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Adenovirus-Mediated Gene Delivery of Tissue Inhibitor of Metalloproteinase-1 Inhibits Migration of B16F10 Melanoma Cell in Wound Migration Assay

  • Seungwan Jee (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Hoil Kang (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Park, Sehgeun (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Park, Misun (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Miok Eom (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Taikyung Ryeom (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Kim, Okhee (Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration)
  • Published : 2003.10.01
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Abstract

Tumor cell invasion and metastasis are a complex multistep process that involves the degradation of extracellular matrix proteins by matrix metalloproteinases (MMPs). Tissue inhibitor of metalloproteinase-1 (TIMP-1) acts as a negative regulator of matrix metalloproteinase and thus prevents tumor cell invasion and metastasis by preserving extracellular matrix integrity.(omitted)

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