Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2003.10b
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- Pages.166-166
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- 2003
Cytochrome P-450 3A4 Proximal Promoter Activity by Histone Deacetylase Inhibitor in Hepg2 Cells
- Kim, Ja-Young (College of Pharmacy, Ewha Womans University) ;
- Ahn, Mee-Ryung (Toxicological Research, Korea Food ＆ Drug Administration) ;
- Sheen, Yhun-Yhong (College of Pharmacy, Ewha Womans University)
- Published : 2003.10.01
Abstract
Cytochrome P-450 3A4 (CYP3A4) is major enzyme in human liver, the role of this is detoxification and metabolizing more than 50% clinical drugs in use. The transcription of CYP3A4 is regulated by the Pregnenolone X receptor (PXR),of which human form is Steroid and Xenobiotics receptor (SXR).(omitted)