한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2003년도 추계학술대회
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- Pages.152-152
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- 2003
Dna Methylation is Involved in the Regulation. of Mouse Cyp1A2 Expression
- Bowhan Jin (College of Veterinary Medicine, Seoul National University) ;
- Park, Dukwoong (College of Veterinary Medicine, Seoul National University) ;
- Kim, Gyongsun (College of Veterinary Medicine, Seoul National University) ;
- Ryu, Doug-Young (College of Veterinary Medicine, Seoul National University)
- 발행 : 2003.10.01
초록
Cytochrome P450 1A2 (CYP1A2) is constitutively and inducibly expressed preferentially in liver of mice, but the molecular mechanisms underlying the expression of CYP1A2 have not yet been fully clarified. In this study, CpG sites of the Cyp1a2 promoter in liver were found to be hypomethylated in a site-specific pattern compared to those in lung and kidney.(omitted)