Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2003.10b
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- Pages.150-150
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- 2003
Single and 28-Day Repeated Intramuscular dose Toxicity Studies of Botulinum Toxin Type a in Rats
- Woo S. Koh (Korea Institute of Toxicology) ;
- Moon-K. Chung (Korea Institute of Toxicology) ;
- Kim, Yong B. (Korea Institute of Toxicology) ;
- Chang S. Ha (Korea Institute of Toxicology) ;
- Gi H. Yang (Medy-Tox) ;
- Hyun H. Chung (Medy-Tox) ;
- Tae C. Jeong (College of Pharmacy Yeungnam University)
- Published : 2003.10.01
Abstract
Botulinum toxin type A was intramuscularly administered to Sprague-Dawley rats in both single and 28-day repeated dose toxicity studies. In the single dose toxicity study performed at 25, 50, 100, and 200 ng/kg, LD50 was estimated to be 70.71 ng/kg for males and 97.63 ng/kg for females.(omitted)