Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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A Ginseng Saponin Metabolite-Induced Apoptosis in HepG2 Cells Involves a Mitochondria-Mediated Pathway and its Downstream Caspase-8 Activation and Bid Cleavage

  • Published : 2003.10.01
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Abstract

20-O-(${\beta}$-D-Glucopyranosyl)-20(S)-protopanaxadiol (IH901), an intestinal bacterial metabolite of ginseng saponins formed from ginsenosides Rb1, Rb2 and Rc, is suggested to be a potential chemopreventive agent. Here we show that IH901 induces apoptosis in human hepatoblastoma HepG2 cells.(omitted)

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