Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2003.10b
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- Pages.143-143
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- 2003
Retrovirus-mediated Gene Delivery of TIMP-2 Inhibits Invasiveness, Motility and Angiogenesis
- Ahn, Seong-Min (College of Pharmacy, Duksung Women′s University) ;
- Seojin Jeong (College of Pharmacy, Duksung Women′s University) ;
- Kim, Yeon-Soo (Inje University) ;
- Yeowon Sohn (Korea Food and Drug Administration) ;
- Aree Moon (College of Pharmacy, Duksung Women′s University)
- Published : 2003.10.01
Abstract
The matrix metalloproteases (MMPs) play important roles in invasion, metastasis and angiogenesis in various cell types. An endogenous inhibitor of MMP, tissue inhibitor of metalloprotease-2 (TIMP-2), has high specificity for MMP-2. An imbalance between MMP-2 and TIMP-2 causes the degradation of the extracellular matrix associated with pathological events including invasion, metastasis and angiogenesis.(omitted)