Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2003.10b
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- Pages.134-134
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- 2003
Induction of Heme Oxygenase-1 by 15-Deoxy-Δ12,14 Prostaglandin J2 in Pc12 Cells: Implications for Protection Against Oxidative cell Death
- Kim, Ji-Woo (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University) ;
- Jang, Jung-Hee (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University) ;
- Surh, Young-Joon (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University)
- Published : 2003.10.01
Abstract
Oxidative stress induced by reactive oxygen intermediates (ROIs) has been implicated in a variety of human diseases including cancer, diabetes, rheumatoid arthritis and neurodegenerative disorders. Hydrogen peroxide (H2O2), a representative ROI which is produced during the cellular redox process, can cause cell death via apoptosis and/or necrosis depending on its concentrations.(omitted)