Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Induction of Heme Oxygenase-1 by 15-Deoxy-Δ12,14 Prostaglandin J2 in Pc12 Cells: Implications for Protection Against Oxidative cell Death

  • Kim, Ji-Woo (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University) ;
  • Jang, Jung-Hee (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University) ;
  • Surh, Young-Joon (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University)
  • Published : 2003.10.01
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Abstract

Oxidative stress induced by reactive oxygen intermediates (ROIs) has been implicated in a variety of human diseases including cancer, diabetes, rheumatoid arthritis and neurodegenerative disorders. Hydrogen peroxide (H2O2), a representative ROI which is produced during the cellular redox process, can cause cell death via apoptosis and/or necrosis depending on its concentrations.(omitted)

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