Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2003.10b
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- Pages.114-114
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- 2003
Mild Hyperthermia-induced Cell Cycle Arrest under P53-dependent Pathway in Human Cells
- Jung, Hwa-Jin (Department of Pharmacology, College of Medicine, Kyung Hee University) ;
- Yim, Sung-Vin (Department of Pharmacology, College of Medicine, Kyung Hee University) ;
- Park, Seungjoon (Department of Pharmacology, College of Medicine, Kyung Hee University) ;
- Jung, Joo-Ho (Department of Pharmacology, College of Medicine, Kyung Hee University) ;
- Jung, Jee-Chang (Department of Pharmacology, College of Medicine, Kyung Hee University) ;
- Seo, Young-Rok (Department of Pharmacology, College of Medicine, Kyung Hee University, Corresponding author)
- Published : 2003.10.01
Abstract
p53 has identified as a tumor suppressor protein to protect cells from DNA damage. p53, also well known for a transcription factor, can activate genes such as p21, bax, gadd45 and induce a number of the responses such as differentiation, senescence, DNA repair, apoptosis and the inhibition of angiogenesis to protect cells. Many mechanisms of p53 activation have been studied.(omitted)