Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Possible Involvement of 15-Deoxy-$\Delta^{12,14}$ prostaglandin $\textrm{J}_2$ in ET-18-O-$\textrm{CH}_3$-Induced Apoptosis in H-Ras Transformed Human Breast Epithelial (MCF10A-ras) Cells

  • Na, Hye-Kyung (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University) ;
  • Surh, Young-Joon (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University)
  • Published : 2003.05.01
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Abstract

It has been known that elevated levels of COX-2 is associated with resistance to apoptosis in cancerous or transformed cells. However, recent studies have shown that up-regulation of COX-2 may be implicated in induction of apoptosis. Previous studies from this laboratory have shown that a novel alkylphospholipid type antitumor agent ET-18-O-$CH_3$ (l-O-octadecyl-2-0-methyl-glycero-3-phosphocholine) induces COX-2 expression in H-ras transformed human breast epithelial cells (MCF10A-ras) while it causes apoptosis in the same concentration range.(omitted)

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