Protective Effects of Naturally Occurring Antioxidants against beta-Amyloid-Induced Oxidative and Nitrosative Cell Death

  • Jang, Jung-Hee (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University) ;
  • Surh, Young-Joon (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University)
  • Published : 2003.05.01

Abstract

beta-Amyloid peptide is considered to be responsible for the formation of senile plagues that accumulate in the brains of patients with Alzheimers disease. There has been a paucity of evidence to support the involvement of reactive oxygen and/or nitrogen species (ROS and/or RNS) in beta-amyloid-induced neuronal cell death. (omitted)

Keywords