한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)

한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지

15-DEOXY-$\Delta^{12,14}$ PROSTAGLANDIN $\textrm{J}_2$ RESCUES PC12 CELLS FROM HYDROGEN PEROXIDE-INDUCED APOPTOSIS THROUGH POTENTIATION OF CELLULAR ANTIOXIDATIVE DEFENSE CAPACITY

  • Kim, Ji-Woo (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University) ;
  • Jang, Jung-Hee (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University) ;
  • Surh, Young-Joon (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University)
  • 발행 : 2003.05.01
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초록

Oxidative stress induced by reactive oxygen intermediates (ROIs) has been implicated in a variety of human diseases including cancer, diabetes, rheumatoid arthritis and neurodegenerative disorders. Hydrogen peroxide ($H_2O$$_2$), a representative ROI which is produced during the cellular redox process, can cause cell death via apoptosis and/or necrosis depending on its concentrations. (omitted)

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