한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2003년도 춘계학술대회 논문집
- /
- Pages.81-82
- /
- 2003
Protective Effect of Celecoxib Against Nitric Oxide-Induced Inflammatory Cell Death in Rat Pheochromocytoma (PC12) Cells
- Li, Mei-Hua (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University) ;
- Jang, Jung-Hee (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University) ;
- Surh, Young-Joon (Laboratory of Biochemistry and Molecular Toxicology, College of Pharmacy, Seoul National University)
- 발행 : 2003.05.01
초록
Recent studies suggest that inflammatory events are implicated in a variaty of human diseases such as cancer and neurodegenerative diseases, and non-steroidal anti-inflammatory drugs have beneficial effects for the treatment or prevention of these disorders. Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in the prostaglandin(PG) synthesis, is induced by various pro-inflammatory stimuli including nitric oxide(NO) and has been reported to cause and/or aggravate neuronal cell death.(omitted)
키워드