Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2003.05a
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- Pages.77-77
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- 2003
Modulation of human cytochrome P450 1B1 by 2,3',4,5'-tetramethoxystilbene(TMS) in mammary tumor cells and its application for cancer chemotherapy
- Lee, Sang-Kwang (College of Pharmacy, Chungang University) ;
- Kim, Sanghee (Korea and Natural Products Research Institute, Seoul National University) ;
- Kim, Mie-Young (Korea and Natural Products Research Institute, Seoul National University) ;
- Chun, Young-Jin (Korea and Natural Products Research Institute, Seoul National University)
- Published : 2003.05.01
Abstract
We have previously shown that 2, 3' , 4, 5' -tetramethoxystilbene(TMS), a trans-stilbene analogue, is one of the most potently selective inhibitor of recombinant human cytochrome P450 1B1 in vitro. In the present studies, the effects of TMS on the expression of cytochrome P450 1B1 were investigated in human mammary cell lines such as MCF-7 and MCF-10A. (omitted)
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