한국독성학회:학술대회논문집 (Proceedings of the Korean Society of Toxicology Conference)
- 한국독성학회 2003년도 춘계학술대회 논문집
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- Pages.68-69
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- 2003
Tributyltin induce apoptosis by disturbance of $\textrm{Ca}^{+}$ and mitochondrial activity, causing oxidative stress and activation of caspases in R2C
- Lee, Kyung-Jin (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University) ;
- Shin, Dong-Weon (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University) ;
- Kim, Ji-Young (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University) ;
- Oh, Duk-Hee (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University) ;
- Cho, Young-Rhan (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University) ;
- Park, Chul-Yung (Division of Food Science, Jinju International University) ;
- Jeong, Hye-Gwang (Department of Pharmacy, College of Pharmacy, Research Center for Proteineous Materials, Chosun University)
- 발행 : 2003.05.01
초록
Tributyltin (TBT) used world-wide in antifouling paints for ships is a widespread environmental pollutant and cause reproductive organs atrophy in rodents. At low doses, antiproliferative modes of action have been shown to be involved, whereas at higher doses apoptosis seems to be the mechanism of toxicity in reproductive organs by TBT. (omitted)