Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2003.05a
- /
- Pages.60-61
- /
- 2003
Effects of butylated hydroxyanisole on glutathione S-transferase activity and cyclophosphamide-induced teratogenicity
-
Kang, Hyun-Gu
(College of Veterinary Medicine, Chungbuk National University)
;
- Lee, Chang-Hee (College of Veterinary Medicine, Chungbuk National University) ;
- Lee, Ki-Chang (College of Veterinary Medicine, Chungbuk National University) ;
- Lee, Jee-Eun (College of Veterinary Medicine, Chungbuk National University) ;
- Kim, Ha-Jung (College of Veterinary Medicine, Chungbuk National University) ;
- Park, Ehn-Kyoung (College of Veterinary Medicine, Chungbuk National University) ;
-
Kim, Yun-Bae
(College of Veterinary Medicine, Chungbuk National University)
- Published : 2003.05.01
Abstract
Effects of repeated treatment with butylated hydroxyanisole (BRA) on the induction of glutathione S-transferases (GSTs) and teratogenicity of cyclophosphamide were investigated in rats. Pregnant rats were orally treated with BRA (50 mg/kg) for 7 days, from days 6 to 12 of gestation, and subcutaneously challenged with cyclophosphamide (15 mg/kg) 2 hr after the final treatment. On day 20 of gestation, the maternal and fetal abnormalities were examined.(omitted)
Keywords