13 Weeks Repeated-Dose Toxicity Studies of 3-Monochloropropane-l,2-diol in Rats

  • Shin, Dong-Hwan (Department of General Toxicology, National Institute of Toxicological Research) ;
  • Oh, Jae-Ho (Department of General Toxicology, National Institute of Toxicological Researc) ;
  • Kim, Sheen-Hee (Department of General Toxicology, National Institute of Toxicological Researc) ;
  • Hwang, Myung-Sil (Department of General Toxicology, National Institute of Toxicological Researc) ;
  • Lim, Chul-Joo (Department of General Toxicology, National Institute of Toxicological Researc) ;
  • Yum, Young-Na (Department of General Toxicology, National Institute of Toxicological Researc) ;
  • Yang, Ki-Hwa (Department of General Toxicology, National Institute of Toxicological Researc) ;
  • Cho, Dae-Hyun (Department of General Toxicology, National Institute of Toxicological Research)
  • 발행 : 2003.05.01

초록

Certain chlorinated propanols occur as contaminants in hydrolysed vegetable proteins. Processing of defatted vegetable proteins by traditional hydrochloric acid hydrolysis leads to the formation of 3-monochloro-1, 2-propanediol(3-MCPD). The objective of this study was to determine the toxicity of 3-MCPD in the rat following oral(gavage) administration for 13 weeks. (omitted)

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