Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2003.05a
- /
- Pages.50-50
- /
- 2003
Downregulation of inducible nitric oxide synthase expression by a ceramide analogue in RAW 264.7 murine macrophages
- Park, Sung-Sik (College of Pharmacy, Chung-Ang University) ;
- Chulbu Yim (College of Pharmacy, Chung-Ang University) ;
- Kim, Mie-Young (College of Pharmacy, Chung-Ang University) ;
-
Chun, Young-Jin
(College of Pharmacy, Chung-Ang University)
- Published : 2003.05.01
Abstract
Nitric oxide (NO) has been studied and found to be an important intracellular modulator. The excess NO produced by the inducible nitric-oxide synthase (iNOS) is implicated in various inflammatory diseases and cellular injury. Inflammatory cytokines such as TNF- or IL-6 increase intracellular ceramide and ceramide may induce NO production and inflammation. (omitted)
Keywords