Molecular Immunological Markers for the Toxicological Investigation: Experiences from Lead-Induced Immunotoxicities

  • Yong Heo (Catholic University of Daegu, Dept. Occupational Health) ;
  • David A. Lawrence (New York State Dept. Health, Wadsworth Center, Clinical & Experimental Endocrinology and Immunolog) ;
  • Kim, Hyoung-Ah (The Catholic University of Korea, College of Medicine, Dept. Preventive Medicine)
  • 발행 : 2003.05.01

초록

Molecular immunological methods are extensively applied to toxicological investigations. Furthermore, various immunological markers have been developed to substantiate molecular mechanisms of xenobiotics-mediated immunotoxicities. We discuss molecular immunological approach to evaluate lead (Pb)-induced immune alteration resulting in suppression of IFN${\gamma}$ production, and its value for establishing useful immunotoxicological markers.(omitted)

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