한국생물물리학회:학술대회논문집 (Proceedings of the Korean Biophysical Society Conference)
- 한국생물물리학회 2003년도 정기총회 및 학술발표회
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- Pages.61-61
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- 2003
Roles of Glutathione Reductase and $\gamma$ -Glutamylcysteine Synthetase in Candida albicans
- Baek, Yong-Un (Laboratory of Biophysics, School of Biological Sciences, and Institute of Microbiology, Seoul National University) ;
- Yim, Hyung-Soon (Laboratory of Biophysics, School of Biological Sciences, and Institute of Microbiology, Seoul National University) ;
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Kang, Sa-Ouk
(Laboratory of Biophysics, School of Biological Sciences, and Institute of Microbiology, Seoul National University)
- 발행 : 2003.06.01
초록
We have cloned the CGR1 gene encoding glutathione reductase (GR) which catalyzes the reduction of oxidized glutathione (GSSG) to reduced glutathione (GSH) from Candida albicans. The cgr1/cgr1 mutants were not viable when CaMAL2 promoter repressed the CGR1 expression. The growth of the mutants could be partially overcome by thiol compounds such as GSH, dithiothreitol, cysteine, N-acetylcysteine and GSSG. Interestingly, C. albicans with CGR1 overexpressed showed defective hyphal growth on solid medium and attenuated virulence. We have also cloned the GCS1 gene encoding
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