한국환경독성학회:학술대회논문집 (Proceedings of the Korea Society of Environmental Toocicology Conference)
- 한국환경독성학회 2003년도 춘계학술대회
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- Pages.186-186
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- 2003
Cytotoxicity and Genotoxicity Study of CKD-712 in Mammalian Cell System
- Kim, Eun-Young (Toxicology Laboratory, Korea Institute of Science & Technology) ;
- Yun, Hye-Jung (Toxicology Laboratory, Korea Institute of Science & Technology) ;
- Kim, Youn-Jung (Toxicology Laboratory, Korea Institute of Science & Technology) ;
- Ryu, Jae-Chun (Toxicology Laboratory, Korea Institute of Science & Technology)
- 발행 : 2003.05.01
초록
CKD-712, named S-YS49 is a chiral compound derived from higenamine (one component of Aconite spp.) derivatives. To compare the cytotoxicity of CKD-712 between in the absence and in the presence of S9 metabolic activation system, we performed trypan blue dye exclusion assay in Chinese hamster lung (CHL) cell. In CHL cells, the cytotoxicity (IC50) of CKD-712 was 92.9
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