Proton MR Spectroscopic Changes in Parkinson′s Disease

  • 백현만 (가톨릭대학교 의과대학 의공학교실) ;
  • 최보영 (가톨릭대학교 의과대학 의공학교실) ;
  • 손병철 (가톨릭대학교 의과대학 신경과학교실) ;
  • 정성택 ((주)메디너스) ;
  • 이형구 (가톨릭대학교 의과대학 의공학교실) ;
  • 서태석 (가톨릭대학교 의과대학 의공학교실)
  • 발행 : 2003.10.01

초록

Purpose: To investigate whether there are significant changes in regional brain metabolism in patients with Parkinson's disease after thalamotomy using proton magnetic resonance spectroscopy (1H MRS). Materials and methods: Fifteen patients with Parkinson's disease of mean age 56.5 years (7 males and 8 females; mean age, 56.5 years) that have treated with levodopa were included. All patients with tremor experienced amelioration of their symptoms on the side contralateral to the thalamotomy. As a single-voxel technique, 1H MR spectra were obtained from the volume of interested regions in thalamus and primary motor cortex. Spectral parameters were: 20 ms TE, 2000 ms TR, 128 averages, 2500 Hz spectral width, and 2048 data points.

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