Proton MR Spectroscopic Changes in Parkinson′s Disease

Purpose： To investigate whether there are significant changes in regional brain metabolism in patients with Parkinson's disease after thalamotomy using proton magnetic resonance spectroscopy (1H MRS). Materials and methods： Fifteen patients with Parkinson's disease of mean age 56.5 years (7 males and 8 females； mean age, 56.5 years) that have treated with levodopa were included. All patients with tremor experienced amelioration of their symptoms on the side contralateral to the thalamotomy. As a single-voxel technique, 1H MR spectra were obtained from the volume of interested regions in thalamus and primary motor cortex. Spectral parameters were： 20 ms TE, 2000 ms TR, 128 averages, 2500 Hz spectral width, and 2048 data points.