Proceedings of the KSAR Conference (한국동물번식학회:학술대회논문집)
- 2003.06a
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- Pages.90-90
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- 2003
The Mouse Mutations Circling and Spinner are Allelic
- Kyoung in Cho (Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical College, Department of Medical genetics, Hallym University) ;
- Lee, Eun-Ju (Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical College) ;
- Kim, Myoung-Ok (Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical College) ;
- Kim, Sung-Hyun (Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical College) ;
- Pakr, Jun-Hong (Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical College) ;
- Jung, Boo-Kyung (Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical College) ;
- Kim, Hee-Chul (Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical College) ;
- Sol ha Hwang (Laboratory Animal Center, Catholic Research Institutes of Medical Science, Catholic Medical College, Department of Medical Genetics, Hallym University) ;
- Suh, Jun-Gyo (Department of Medical Genetics, Hallym University)
- Published : 2003.06.01
Abstract
Circling mice were recorded to display profound deafness and a head-tossing and bidirectional circling behavior, showing an autosomal recessive mode of inheritance. In addition, the histological examination of inner ears revealed that the region around organ of Corti, spiral ganglion neurons and outer hair cells showed definite abnormality. On the other hand, a genetic linkage map was constructed in an intraspecific backcross between cir and C57BL/6J mice. The cir gene was mapped to a region between D9Mitl16/D9Mit15 and D9Mit38 on the mouse chromosome 9. Estimated distances between cir and D9Mitl16, and between cir and D9Mit38 are 0.70