Proceedings of the Korean Society of Developmental Biology Conference (한국발생생물학회:학술대회논문집)
- 2003.10a
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- Pages.71-71
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- 2003
Estrogen Mediates Ischemic Damage and the Migration of Human Umbilical Cord Blood Cells
- Kim, Jee-Yun (Department of Biotechnology & Biomedical Science, Inje University) ;
- Yu, Seong-Jin (Department of Biotechnology & Biomedical Science, Inje University) ;
- Kim, Do-Rim (Department of Biotechnology & Biomedical Science, Inje University) ;
- Youm, Mi-Young (Department of Biotechnology & Biomedical Science, Inje University) ;
- Lee, Chae-Kwan (Institute of Industrial Medicine, Inje University) ;
- Kang, Sung-Goo (Department of Biotechnology & Biomedical Science, Inje University)
- Published : 2003.10.01
Abstract
Human umbilical cord blood cells(HUCBC) are rich in mesenchymal progenitor cells, endothelial cell precursors and hematopoietic cells. HUCBC have been used as a source of transplantable stem and progenitor cells. However, little is known about survival and development of HUCBC transplantation in the CNS. Estrogen has a neuroprotective potential against oxidative stress-induced cell death so has an effect on reducing infarct size of ischemic brain. We investigated the potential use of HUCBC as donor cells and tested whether estrogen mediates intravenously infused HUCBC enter and survive in ischemic brain. PKH26 labeled mononuclear fraction of HUCBC were injected into the tail vein of ischemic OVX rat brain with or without