Proceedings of the Korean Society of Developmental Biology Conference (한국발생생물학회:학술대회논문집)
- 2003.10a
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- Pages.67-67
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- 2003
Effects of Tributyltin Chloride (TBTCI) on Reproductive Organs and Steroidogenic Enzymes
- Ki, Ho-Youn (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FDA) ;
- Lee, Su-Jung (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FDA) ;
- Shin, Jae-Ho (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FDA) ;
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Kang, Il-Hyun
(Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FDA) ;
- Moon, Hyun-Ju (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FDA) ;
- Kim, Tae-Sung (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FDA) ;
- Hoon Bae (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FDA) ;
- Dong, Mi-Sook (Graduate School of Biotechnology, Korea University) ;
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Yoon, Yong-Dal
(Department of Life Science, College of Natural Sciences, Hanyang University)
- Published : 2003.10.01
Abstract
Tributyltin chloride (TBTCI) is an organotin compounds that have been widely used as antifouling agents and bioaccumulated in the food chain. TBTCI has been known to induce imposex in female gastropods. There are several reports that TBTCI increased testosterone level and inhibited the conversion of testosterone to estradiol by the aromatase cytochrome P450 enzyme. In this studies, we investigated the effects of TBTCI on steroidogenesis in testes, We dosed to 4-week-old Spragus-Dawleys (SD) male rats with TSTCI (0, 1, 5, 10, and 20mg/kg/day) daily by gavage for 14 days. TBTCI significantly decreased the weights of seminal vesicle, prostate, cowper's gland and LABC at 10 and 20mg/kg/day but significantly Increased the weights of liver at 10 and 20mg/kg/day and adrenals at 20mg/kg/day. mRNA levels of steroidogenic acute regulatory (StAR) and P450 aromatase were decreased and mRNA levels of cytochrome P450 17