한국발생생물학회:학술대회논문집 (Proceedings of the Korean Society of Developmental Biology Conference)
- 한국발생생물학회 2003년도 제3회 국제심포지움 및 학술대회
- /
- Pages.26-28
- /
- 2003
Epigenetics by DNA Methylation for Normal and Cloned Animal Development
- Shiota, Kunio (Cellular Biochemistry, Animal Resource Sciences / Veterinary Medical Sciences, University of Tokyo)
- 발행 : 2003.10.01
초록
"Epigenetics" means the study of heritable changes in gene-activity without changes in DNA sequences. Methylation of the cytosine residue in a CpG dinucleotide sequence is a characteristic of the vertebrate genome. In vertebrates, methylation of DNA mainly occurs at the 5′-position of cytosine in a CpG dinucleotide forming 5-methylcytosine. Methylation of DNA plays a profound role in transcriptional repression of gene expression through several mechanisms. Generally, DNA of inactive genes is more heavily methylated than that of active ones; conversely demethylation of DNA reactivates gene expression in vivo and in vitro.
키워드