Development of controlled releasing drug (CRD) for root canal disinfection

I. Objectives Endodontic disease is caused primarily by bacteria that interact with periradicular host from the root canal system. Chlorhexidine gluconate is known to effective to eliminate Enterococcus faecalis which resists to other intracanal medicaments. The aim of this in vitro study was to develop a slowly releasing root canal disinfectant using using chlorhexidine gluconate and chitoic acid. II. Materials and Methods Three different group were prepared with different drug release mechanism. In group A, paper points as used core material were loaded with 20% chlorhexidine gluconate.(omitted)