Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)

The Korean Society of Applied Pharmacology (한국응용약물학회)
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New possibility of chlorogenic acid treatment on skin aging

  • Lee, J.C. (Skin research Institute, AmorePacific Corporation) ;
  • Kim, J.H. (Skin research Institute, AmorePacific Corporation) ;
  • Ahn, S.M. (Skin research Institute, AmorePacific Corporation) ;
  • Chung, J.H. (Skin research Institute, AmorePacific Corporation) ;
  • Lee, B.G. (Department of Dermatology, Seoul National University College of Medicine, Seoul National University Hospital) ;
  • Chang, I.S. (Skin research Institute, AmorePacific Corporation) ;
  • Published : 2003.11.01
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Abstract

It is well-documented that decreased antioxidant defense system by ultraviolet(UV) irradiation is the most important reason to induce the skin aging, especially photoaging. Chlorogenic acid(CA), a nonflavonoid catecholic compound, is present in the diet as part of fruits, tea, coffee and wine and has been reported to have anti-inflammatory, antimutagenic and anticarcinogenic activities. In this study, we examined the effects of CA on the UV -induced photoaging. Firstly, we investigated the protective effect of CA on antioxidant defense system in HaCaT human keratinocytes after UV irradiation treatment. UV irradiation decreased antioxidant defence enzyme activities of superoxide dismutase, catalase and GSH contents, which were restored by CA. To elucidate the effect of CA, 1% of CA and vehicle were applied to human buttock skin before and after UV irradiation (2MED). CA prevented UV -induced matrix metalloproteinase-1 mRNA expression and procollagen mRNA depression. And CA also increased CD1a(Langerhans cell) expression significantly. Our results suggest that CA has protective effects on UV -induced photoaging by increasing cellular antioxidant defense system. Therefore, CA may be a useful anti-aging agent for cosmetic purpose.

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