Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Rubus croceacanthus Leveille inhibits mast cell-mediated immediate-type allergic reactions and tumor necrosis factor-$\alpha$ secretion

  • Moon, Phil-Dong (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Department of Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Park, In-Young (Department of Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Na, Ho-Jeong (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Department of Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Hong, Seung-Heon (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University) ;
  • Kim, Hyung-Min (Department of Pharmacology, College of Oriental Medicine, Kyung Hee University)
  • Published : 2003.11.01
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Abstract

We studied the effect of Rubus croceacanthus Leveille (RCL) on mast cell-mediated anaphylactic reactions. RCL inhibited compound 48/80-induced systemic anaphylactic shock. When RCL was given at concentrations ranging from 0.01 to 1 mg/$m\ell$, the histamine release from rat peritoneal mast cells induced by compound 48/80 was reduced in a dose-dependent manner. RCL also inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl IgE. In addition, RCL inhibited phorbol 12-myristate 13-acetate and A23187-induced tumor necrosis factor-${\alpha}$ secretion from human mast cell line HMC-1 cells. These results indicate that RCL may possess a strong anti-anaphylactic activity.

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