한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
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- Pages.85-85
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- 2003
Chemosensitizing Activity Against Human Leukemia Cell of Crude Extracts of Native Camellia(Camellia japonica) in Jeonnam
- Hwang, Eun-Ju (Division cf Biotechnology, Dongshin University) ;
- Lee, Sook-Young (Biology Research Center for Industrial Accelerators, Dongshin University)
- 발행 : 2003.11.01
초록
This study has been undertaken to increase availability of native camellia in Jeonnam as a medicinal resource and to isolate the effective components from them. Multidrug resistance(MDR) by tumor cells is a major obstacle to successful cancer chemotherapy. We report that the crude extracts of camellia flowers, leaves has a chemosensitizing effect that can reverse Pgp-mediated MDR by increasing the intracellular accumulation of drugs. The cytotoxic and chemosensitizing effects of MeOH extract from 12 spp. citrus fruits on the AML-2/D100 were determined using MTT assay. Chemosensitizing effects was screened in the presence of vincristine, a good substrate of Pgp. IC
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