한국응용약물학회:학술대회논문집 (Proceedings of the Korean Society of Applied Pharmacology)
- 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
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- Pages.84-84
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- 2003
The effect of lead on matrix metalloproteinase-9 expression in rat primary glial cells
- Park, Min-Sik (Department of Pharmacology, College of Pharmacy, Seoul National University) ;
- Lee, Woo-Jong (Department of Pharmacology, College of Pharmacy, Seoul National University) ;
- Kim, Young-Eun (Department of Pharmacology, College of Pharmacy, Seoul National University) ;
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Ko, Kwang-Ho
(Department of Pharmacology, College of Pharmacy, Seoul National University)
- 발행 : 2003.11.01
초록
Lead has long been considered as a toxic environmental pollutant, which severely damages central nervous system. Lead can cause hypo- and de-myelination, and glial cells are closely related with myelination or demyelination. Matrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in the remodelling of the extracellular matrix in a variety of physiological and pathological processes. MMPs also seem to be important in the pathogenesis of inflammatory demyelinating diseases of the central and peripheral nervous system. In this study, we investigated whether lead affects MMP-9 expression in rat primary glial cells. Treatment of 0.1-5
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