Proceedings of the Korean Society of Applied Pharmacology (한국응용약물학회:학술대회논문집)
- 2003.11a
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- Pages.37-43
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- 2003
The role of macrophage in lipid accumulation
- Ishii, Itsuko (Laboratory of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University)
- Published : 2003.11.01
Abstract
Engorgement of macrophages with cholesterol is the defining pathological characteristic of atherosclerotic plaques, the cause of most heart attacks and strokes. Activated human macrophages uptake low density lipoprotein (LDL) by the bulk-phase fluid, and aggregated LDL by patocytosis. After incorporation of LDL and aggregated LDL into macrophages, neutral cholesterol esterase is decreased and cholesterol efflux is also deceased, resulting that macrophages become foam cells.
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