Proceedings of the Korea Crystallographic Association Conference (한국결정학회:학술대회논문집)
- 2003.05a
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- Pages.14-14
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- 2003
Structural basis of Shank PDZ interaction with the C-terminal peptide of GKAP protein and the mode of PDZ domain dimerization
- Im, Young-Jun (Kwangju Institute of Science & Technology) ;
- Lee, Jun-Hyuck (Kwangju Institute of Science & Technology) ;
- Park, Seong-Ho (Kwangju Institute of Science & Technology) ;
- Park, Seong-Hwan (Kwangju Institute of Science & Technology) ;
- Park, Soo-Jeong (Kwangju Institute of Science & Technology) ;
- Kang, Gil-Bu (Kwangju Institute of Science & Technology) ;
- Kim, Eunjoon (Kwangju Institute of Science & Technology) ;
- Eom, Soo-Hyun (Kwangju Institute of Science & Technology)
- Published : 2003.05.01
Abstract
We have crystallized and determined the structures o the Shank PDZ domain, alone and in complex with the synthetic C-terminal hexapeptide of GKAP protein at resolutions of 1.8Å and 2.5Å, respectively. The structure revealed the structural basis of the ligand recongition by Class I PDZ-ligand interaction. Moreover, dimeric structureof shank PDZ domain suggests that the βA strand is a common surface for dimerization of PDZ domains.
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