한국생물공학회:학술대회논문집
- 한국생물공학회 2002년도 생물공학의 동향 (X)
- /
- Pages.524-527
- /
- 2002
Improved modeling of non-hepatic cellular uptake and degradation of low density lipoprotein
초록
인간 fibroblasts의 receptor를 통한 LDL의 섭취와 분해에 대하여 보다 개선되어진 수학적/동역학적 모델을 제시하였다. 관련된 동역학적 모델의 hierarchy를 통하여 세포 멤브레인 표면으로 recycle되는 receptor의 선택적 insertion 정도를 나타내는 파라미터,
An improved mathematical/kinetic model is proposed to describe receptor-mediated uptake and its degradation of LDL on human fibroblasts. The hierarchy of kinetic models is presented, which leads to the model introducing the parameter of degree of preferential insertion of recy치ed receptors to the surface of cell membrane. The results of its prediction were presented in various types of experimental and in various LDL concentrations. Its ability to predict Brown and Goldstein’s ample experimental data was excellent.
키워드