한국생물공학회:학술대회논문집

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Colistin 생산균주의 균주개량 및 productivity 증대를 위한 발효최적화

  • 예병대 ((주)제일바이오 연구소 생명공학실) ;
  • 황용배 ((주)제일바이오 연구소 생명공학실) ;
  • 김영희 ((주)제일바이오 연구소 생명공학실) ;
  • 김동건 ((주)제일바이오 연구소 생명공학실) ;
  • 양호석 ((주)제일바이오 연구소 생명공학실)
  • Published : 2002.04.12
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Abstract

Colistin produced from Penibacillius polymyxa was widely used as an antibiotic active against gram-negative bacteria and as feed additive. This research studied on increment of colistin productivity by mutation of P. polymyxa. As a result, several mutants were obtained from the strain by UV radiation and NTG treatment. They produced approximately 8.5${\sim}$9.0 g/L of colistin in flask and jar culture. Colistin productivity of the mutant, named Penibacillius polymyxa CBY, showed 100 times than that of wild type. When Penibacillius polymyxa CBY fermented in the optimal medium, it produced up to 18 g/L of colistin in jar fermentation.

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