대한생식의학회:학술대회논문집
- 대한불임학회 2002년도 제42차 춘계학술대회
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- Pages.11-17
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- 2002
초기 발생에 있어서 복제수정란의 리프로그래밍
Reprogramming of Cloned Embryos During Early Embryogenesis
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Han, Yong-Mahn
(National Research Laboratory for Animal Developmental Control, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
;
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Kang, Yong-Kook
(National Research Laboratory for Animal Developmental Control, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
;
- Koo, Deog-Bon (National Research Laboratory for Animal Developmental Control, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
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Lee, Kyung-Kwang
(National Research Laboratory for Animal Developmental Control, Korea Research Institute of Bioscience and Biotechnology (KRIBB))
- 발행 : 2002.05.10
초록
Animal clones derived from somatic cells have been successfully produced in a variety of mammalian species such as sheep, cattle, mice, goats, pigs, cat and rabbits. However, there are still many unsolved problems in the present cloning technology. Somatic cell nuclear transfer has shown several developmental aberrancies including high rate of abortion in early gestation and increased perinatal death. These developmental failures of cloned embryos may arise from abnormal reprogramming of donor genome and/or incomplete cloning procedure. We have found that overall genomic methylation status of cloned bovine embryos is quite different from that of normal embryos in various genomic regions, suggesting that the developmental failures of cloned embryos may be due to incomplete reprogramming of donor genomic DNA. Many of the advances in understanding the molecular events for reprogramming of donor genome will more clarify the developmental defects of cloned embryos.
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