Proceedings of the Ginseng society Conference (고려인삼학회:학술대회논문집)
- 2002.10a
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- Pages.277-287
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- 2002
Chemopreventive Effects of Ginseng on Rat Carcinogenesis
- Wanibuchi Hideki (Department of Pathology, Osaka City University Medical School) ;
- Ichihara Toshio (Department of Pathology, Osaka City University Medical School) ;
- Morimura Keiichirou (Department of Pathology, Osaka City University Medical School) ;
- Fukushima Shoji (Department of Pathology, Osaka City University Medical School)
- Published : 2002.10.01
Abstract
The chemopreventive effects of ginseng on rat carcinogenesis models were investigated, In the present study, the inhibitory effects of white and red ginseng on tumor development were examined using medium-term liver, initiation and medium-term multi-organ carcinogenicity bioassay systems. No modifying potential of the ginsengs was evident in terms of the numbers or areas of glutathione S-transferase placental form (GST -P)-positive foci, which is a marker of preneoplastic lesion in rat livers. However, white ginseng, but not red ginseng was found to decrease the incidences of adenocarcinoma of the small intestine and colon in the medium-term multi-organ carcinogenesis model. These results indicate that white ginseng may have inhibitory effects on progression stage of rat intestinal carcinogenesis, but the influence is not strong. Ginseng is unlikely to have promoting or inhibitory effects in other organs under the present type of experimental conditions. Possible application on ginseng for chemoprevention of colon cancer in humans, can be concluded given the lack of obvious adverse effects.