Proceedings of the Ginseng society Conference (고려인삼학회:학술대회논문집)
- 2002.10a
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- Pages.227-237
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- 2002
Comparative Studies of Panax ginseng and Panax quinquefolium on TCDD-induced Toxicity in Rats
- Wee Jae Joon (KT&G Central Research Institute) ;
- Choi Seung Hoon (College of Oriental Medicine, Daejeon University) ;
- Park Kyeong Mee (KT&G Central Research Institute) ;
- Kyung Jong Su (KT&G Central Research Institute) ;
- Kang Dae Young (College of Medicine, Chungnam National University) ;
- Song Tae Won (College of Oriental Medicine, Daejeon University)
- Published : 2002.10.01
Abstract
One prominent characteristic of2,3,7,8-tetrachlorodibenzop-dioxin (TCDD) toxicity in rats is a reduction of body weight accompanied by an altered serum lipid profile such as hyperlipidemia. A single administration of TCDD (50 ug/kg) resulted in a decrease of body weight and increase of serum cholesterol in rats. TCDD-induced weight loss and serum cholesterol elevation was reduced in rats administered with water extract (100 mg/kg) or saponin fraction (40 mg/kg) of Panax ginseng C.A.Meyer. In contrast, the administration of Panax quinquefolium did not inhibit the TCDD-induced weight loss and serum cholesterol elevation. Histological examinations of liver and testis revealed the administration of saponin fraction of Panax ginseng attenuated the TCDD-induced hispathologicallesions whereas the administration of saponin fraction of Panax quinquefolium did not. High performance liquid chromatographic analysis demonstrated high percentiles of ginsenoside Rg and ginsenoside
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