한국작물학회:학술대회논문집 (Proceedings of the Korean Society of Crop Science Conference)
- 한국작물학회 2002년도 춘계 학술대회지
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- Pages.77-81
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- 2002
배초향의 생리활성 물질과 항동맥경화 효과
Bioactive compounds and Anti-atherosclerotic Effect of Agastache rugosa
- Lee Hyeong-Kyu (Immunomodulator Research Laboratory, KRIBB) ;
- Oh Sei-Ryang (Immune-modulator Research Laboratory, KRIBB)
- 발행 : 2002.05.01
초록
The scope of the research is investigation of immune-modulating activities of A. rugosa (Baechohyang) extract was preformed through the screening active constituents using in vitro assays and evaluating anti-inflammatory activity and anti-atherosclerotic activity of the extract and active compound (tilianin) in vivo. In addition, various functional foods using the extract and whole plant was developed. The extract showed strong anti-inflammatory activity in carrageenan-induced acute edema mouse model and anti-atherogenic lesion activity in LDLR (low density lipoprotein receptor) deficient mouse model. These activities were thought to be resulted from modulation activity of several pathways of inflammation process. Among the main constituents of Baechohyang, polyunsaturated fatty acids (PUFA), Phytosterols, oleanolic acid and rosmarinic acid showed anticomplement activity, and PUFA, acacetin and tilianin newly showed potent ICAM-1 expression inhibition activity. The processes of extraction, mixing ratio of additives and storage conditions were established for drinks, granule tea, leaf tea, mixed tea and furigake.
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