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Using Polypyrrole for Drug Delivery System

  • 이상조 (단국대학교 전기전자컴퓨터공학부) ;
  • 이승기 (단국대학교 전기전자컴퓨터공학부) ;
  • 오명환 (단국대학교 전기전자컴퓨터공학부) ;
  • 박정호 (고려대학교 전기공학과)
  • 발행 : 2002.11.07

초록

The possibility of using polypyrrole as a drug delivery system(DDS) has been studied using indicate (Phenol red) and substance with therapeutic activity(Sodium salicylate). In aqueous solution, negative potential is applied to polypyrrole then anion(with therapeutic activity) of sodium salicylate is released by redox processes of polypyrrole. The release amount of anionic drugs from polypyrrole is measured by UV-visible spectrometer which can measure UV-absorbance of materials. Electrode area that use for release amount measurement is$50mm^{2}(5{\times}10mm)$,and thickness of polypyrrole membrane is $15{\mu}m$. DC 1V applied in saline solution, the release amount according to time increased gradually. In various electrode area, release amount of anionic drug is directly to electrode area.

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