대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.318.3-319
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- 2002
Peroxynitrite Scavenging Mechanism of Alaternin and Nor-rubrofusarin glucose from Cassia tora
- Park, Tae-Hyun (College of Pharmacy, Pusan National University) ;
- Jung, Hyun-Ah (Food Science and Biotechnology Pykyong National University) ;
- Choi, Jae-Sue (Food Science and Biotechnology Pykyong National University) ;
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Chung, Hae-Young
(College of Pharmacy, Pusan National University)
- 발행 : 2002.10.01
초록
Peroxynitrite(ONOO-), formed from the reaction of superoxide(O2-) and nitric oxide(NO), is a potent oxidant that contributes to oxidation of various cellular constituents including lipids. amino acids, sulphydryls and nucleotides. It can cause cellular injury such as DNA fragmentation and apoptotic cell death. Also. the toxicity of ONOO- has been reported to be involved in inflammatory and nurodegenerative diseases such as Alzheimer's disease, Parkinson's disease. and atherosclerosis. (omitted)
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