대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.356.2-356.2
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- 2002
CoMFA of 1-phenyl-2-substituted thioureas for their cytotoxicity
- Im, C.U. (College of Pharmacy. Chung-ang University) ;
- Park, Kang-Min (College of Pharmacy. Chung-ang University) ;
- Jun, S.C. (College of Pharmacy. Chung-ang University) ;
- Yim, C.B. (College of Pharmacy. Chung-ang University)
- 발행 : 2002.10.01
초록
The structure of 1-phenyl-2-substituted thiourea derivatives have been studied and optimized for their cytotoxic activity. The three dimensional quantitative structure activity relationship (3D-QSAR) was investigated using comparative molecular field analysis (CoMFA). The result suggested that electrostatic and steric factors of 2-alkylureido-1-phenyl propanol derivatives were correlated well with cytotoxic activity. (omitted)
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