Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.426.2-426.2
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- 2002
Nonviral Vector for Efficient Gene Transfer to Human Ovarian Adenocarcinoma Cells
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Kim, Chong-Kook
(College of pharmacy, Seoul national University)
;
- Haider, K.H. (College of pharmacy, Seoul national University) ;
- Choi, Sung-Hee (College of pharmacy, Seoul national University) ;
- Choi, Eun-Jeong (College of pharmacy, Seoul national University) ;
- Ahn, Woong-Shick (College of Medicine, the Catholic University of Korea)
- Published : 2002.10.01
Abstract
Various strategies have been attempted to design efficient protocols for ovarian cancer gene therapy but there has been little progress in their clinical application. In this study, we formulated and evaluated a new cationic liposome composed of dioleoyltrimethylaminopropane (DOTAP), 1.2-dioleoyl-3-phosphophatidylethanolamine (DOPE). and cholesterol (Chol) (DDC) for plasmid DNA transfer into ovarian cancer cells. The DOC liposome was prepared by mixing DOTAP. DOPE. and Chol using extrusion method. (omitted)
Keywords