Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.426.1-426.1
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- 2002
Polyethylene glycol (PEG)-modified cationic liposome mediated gene delivery
- Kim, Jin-Ki (College of pharmacy, Seoul national University) ;
- Choi, Sung-Hee (College of pharmacy, Seoul national University) ;
- Ahn, Woong-Shick (College of Medicine, the Catholic University of Kore) ;
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Kim, Chong-Kook
(College of pharmacy, Seoul national University)
- Published : 2002.10.01
Abstract
In this study. we modified the cationic liposomes by polyethylene glycol (PEG)-grafted or PEG-added methods. The PEG-grafted transfection complexes were prepared by adding the plasmid DNA to the PEG-grafted cationic liposomes, composed of PEG and cationic lipids. PEG-added transfection complexes were prepared by adding the PEG to the mixture of cationic lipids and plasmid DNA. The particle sizes of PEG-modified transfection complexes did not change during storage compared to conventional transfection complexes. (omitted)
Keywords