대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
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POPULATION PHARMACOKINETICS OF TERBINAFINE IN HEALTHY MALE KOREAN SUBJECTS USING NONMEM

  • Kang, Hyun-Ah (College of Pharmacy and Institute of Bioequivalence and Bridging Study Chonnam National University) ;
  • Cho, Hea-Youg (College of Pharmacy and Institute of Bioequivalence and Bridging Study Chonnam National University) ;
  • Lee, Suk (College of Pharmacy and Institute of Bioequivalence and Bridging Study Chonnam National University) ;
  • Lee, Yong-Bok (College of Pharmacy and Institute of Bioequivalence and Bridging Study Chonnam National University)
  • 발행 : 2002.10.01
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초록

The purposes of this study were to evaluate the population pharmacokinetics of terbinafine according to two-compartment model will, lag time and to investigate the influence of characteristics or subjects such as body weight and age on the pharmacokinetic parameters of terbinatine. Serum data from 73 healthy male Korean subjects were used for this analysis. After overnight fast. each subject received a single 125 mg oral dose of terbinafine. (omitted)

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