대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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- Pages.416.1-416.1
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- 2002
A Comparative study for single-shot immunization of diphtheria toxoid with combined PLGA microspheres.
- Yoon, Mi-Kyeung (College of Pharmacy. Chung-Ang University) ;
- Lee, Jung-Min (College of Pharmacy. Chung-Ang University) ;
- Kim, Hee-Kyu (College of Pharmacy. Chung-Ang University) ;
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Choi, Young-Wook
(College of Pharmacy. Chung-Ang University)
- 발행 : 2002.10.01
초록
Biodegradable PLGA microspheres(MS) have been widely studied for delivering antigens because PLGA has the characteristics of various degradation rate. In general. since MS have shown potential for single-dose vaccines. the degradation rate of PLGA is determined by their molecular weight. polymer composition, etc. We studied the influences of molecular weight of PLGA. polymer composition and surfactant on in vitro release and in vivo effects. (omitted)
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