Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.413.3-414
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- 2002
Tissue Distribution of Novel Polymeric Micellar Paclitaxel in Mice
- Kim, Hye-Jin (College of Pharmacy. Ewha Womans University) ;
- Kang, Min-Kyung (College of Pharmacy. Ewha Womans University) ;
- Kim, Kil-Soo (College of Pharmacy. Ewha Womans University)
- Published : 2002.10.01
Abstract
Paclitaxel is a diterpenoid isolated from Taxus brevifolia and is an active anticancer drug for the treatment of ovarian cancer, breast cancer and Kaposi's sarcoma. Due to its low solubility in water, it is dissolved in Cremophor EL(polyethoxylated castor oil) and ethanol, which cause serious side effects including hypersensitivity. BLK460 was developed as a novel polymeric micellar paclitaxel formulation containing Aceporol460 as solubilizer (omitted)
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