Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.412.2-413
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- 2002
Solubilization of poorly water-soluble drugs using solid dispersions
- Kim, Tae-Wan (Biological Rhythm and Controlled Release Lab., College of Pharmacy, Kangwon National University) ;
- Choi, Choon-Young (Pharm Tech Research Incorp) ;
- Cao, Qing-Ri (Pharm Tech Research Incorp) ;
- Lee, Beom-Jin (Pharm Tech Research Incorp.)
- Published : 2002.10.01
Abstract
Purpose. To prepare polymer based physical mixtures or solid dispersions containing solubilizing compositions using a spray-dryer. Methods. Lovastatin.simvastatin.aceclofenac and cisapride were selected as poorly water-soluble drugs. Dextrin. poly(vinylalcohol). poly(vinylpyrrolidone)and polyethylene glycol were chosen as solubilizing carriers for solid dispersions. The solid dispersions containing solubilizing compositions without drug were prepared without using organic solvents or tedious changes of formulation compositions. (omitted)
Keywords