Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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THE RELATIONSHIP OF INTESTINAL ABSORPTION CLEARANCE AND PARTITION COEFFICIENT OF NINE BETA-BLOCKERS IN RATS

  • Cho, Hea-Young (College of Pharmacy and Institute of Bioequivalence and Bridgig Study Chonnam National University) ;
  • Lee, Suk (College of Pharmacy and Institute of Bioequivalence and Bridgig Study Chonnam National University) ;
  • Kang, Hyun-Ah (College of Pharmacy and Institute of Bioequivalence and Bridgig Study Chonnam National University) ;
  • Lee, Yong-Bok (College of Pharmacy and Institute of Bioequivalence and Bridgig Study Chonnam National University)
  • Published : 2002.10.01
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Abstract

On the basis of recognizing that physicochemical properties (lipophilic/hydrophilic), intestinal absorption clearance and pharmacokinetic characteristics of drug are the fundamental parameters controlling the rate and the extent of drug absorption, the biopharmaceutics classification system for the correlation between drug lipid- solubility and intestinal absorption clearance is proposed. (omitted)

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